Endocrine Abstracts

Objective: To assess the management and therapeutic outcomes of non-functioning pituitary adenomas (NFPA) in the Tunisian population.Patients and Methods: We conducted a retrospective descriptive study of 35 patients followed for NFPA between 2000 and 2022 at the endocrinology department of Hedi Chaker University Hospital.Results: The mean age was 52.1±11.4 years, with a male predominance (61.3%). The majority of tumors were bet...

Introduction: Pseudohypoparathyroidism (PHP) type 1a is a genetic disorder associated primarily with resistance to parathyroid hormone (PTH). Its pathogenesis has been linked to dysfunctional G-protein-mediated signaling. Since the G unit is an ubiquitary protein, its mutation can lead to variable hormonal dysfunction. In this context we report the case of a patient followed in our department for multihormone resistance.Case report: A 9 years old boy, bo...

Background and aim: Acromegaly is mostly due to a somatotropic adenoma. Regarding its insidious nature, this adenoma is often revealed at an invasive stage when one or more hormonal insufficiencies are already installed. This study aims to describe the clinical and biological features of hypopituitarism associated with somatotropic adenomas.Patients and Methods : We conducted a retrospective study at the Endocrinology department of Hedi Chaker University...

Introduction: Pituitary adenomas are the most frequent sellar tumors in adults. Depending on their hormonal profile in vivo and on immunohistochemistry, they present different clinical profiles and progression outcomes. Thus, we report a case of an FSH-secreting pituitary adenoma.Observation: The patient SG is 63 years old. He complained of intermittent headaches associated with a progressive decrease in visual acuity. Ophthalmological examinati...

Introduction: Turner syndrome (TS) is a genetic condition, that results from the complete or partial loss of the second X chromosome in phenotypic females. Typically, patients with TS have growth retardation, altered pubertal development and facial dysmorphism. It’s also associated with other comorbidities.Aim: Here we report a rather rare finding which is the association of TS and Rokitansky-Küster Hauser (RKH) and we discuss the possible ethi...

Introduction: Hashimoto’s encephalopathy (HE) is characterised by the combination of clinical signs of encephalitis and autoimmune thyroiditis with elevated levels of antithyroid antibodies (ATA). It is a rare condition and its etiopathogenesis is still poorly understood.Observation: we present a 33-year-old female patient who was hospitalized for gait disorders. The diagnosis of a chronic cerebellar syndrome related to Hashimoto’s encephalitis...

Introduction: Hypothyroidism is a consequence of thyroid hormone deficiency which may be of peripheral or central origin. If hypothyroidism is left untreated, the symptoms progress and lead to life-threatening complications.Patients and method: Retrospective study of 67 patients with primary hypothyroidism. We determined the different complications associated with hypothyroidism.Results: We collected 67 patients with overt hypothyr...

Introduction: Autoimmune bullous dermatoses (ABD) represent a heterogeneous group of AIDs that target different epidermal or subepidermal proteins of the skin and/or mucous membranes. As with any autoimmune disease (AID), it may be associated with other AIDs. We report a case of ABD associated with Graves’ disease (GD).Observation: The ABD was a pemphigus vulgaris (PV) that was diagnosed at the age of 25 years in our patient and she was treated with...

Introduction: Alopecia is an autoimmune disease (AID) affecting the hair follicles. Alopecia can become generalised and affect all hairy areas (universal alopecia). As with any AID, it may be associated with other AIDs. We report 2 cases of the association of alopecia with autoimmune thyroid disease (AITD).Observation: The subjects were a man and a woman aged 48 and 54 years respectively. They presented with hypothyroidism. Hashimoto’s thyroiditis (...

Introduction: Inslinomas are the most common cause of hypoglycemia resulting from endogenous hyperinsulinism. Although rare, they have the potential to produce metabolic derangements, necessitating early diagnosis. The aim of our study was to determine the clinical manifestations, diagnostic methods, treatments used and results of patients with insulinoma.Patients and methods: It’s a retrospective study including 9 patients with insulinoma, diagnose...